Chlormethine: Uses, Dosage, Side Effects and More

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Mycosis fungoides

Adult: In patients with mycosis fungoides-type cutaneous T-cell lymphoma stage IA and IB who have received prior skin-directed therapy: As 0.016% gel: Apply a thin film once daily to the affected area(s). Dosing interruption or discontinuation may be required according to individual safety or tolerability (refer to detailed product guidelines).

Special Precautions

Pregnancy and lactation.

Adverse Reactions

Significant: Accidental eye exposure (e.g. pain, burning, inflammation, photophobia, blurred vision, blindness, severe irreversible anterior eye injury), mucous membrane exposure (e.g. pain, redness and ulceration); hypersensitivity reactions (e.g. anaphylaxis); moderately severe to severe dermatitis; secondary exposure (e.g. mucosal injury); secondary malignancy (e.g. nonmelanoma skin cancer).
Skin and subcutaneous tissue disorders: Local skin reactions (e.g. swelling, inflammation, pruritus, blisters, skin infections, hyperpigmentation).

Pregnancy Category (US FDA)

Intracavitary/IV/Parenteral/Topical: D

Patient Counseling Information

Avoid contact with the eyes, mucous membranes and unaffected areas. Avoid direct skin contact in individuals other than the patient. Women of childbearing potential and men with female partners of childbearing potential must use a barrier method of contraception during treatment.

Monitoring Parameters

Monitor for dermatologic toxicity. Assess for signs and symptoms of nonmelanoma skin cancer (during and after treatment); hypersensitivity reactions.

Action

Description:
Mechanism of Action: Chlormethine, a bifunctional nitrogen mustard alkylating agent, forms inter- and intra-strand DNA cross-links resulting in DNA synthesis inhibition.
Synonym(s): Mechlorethamine.

Chemical Structure

Storage

Unopened tube (prior to dispensing): Store between -15 to -25°C. After defrosting: Store between 2-8°C. This is a cytotoxic drug. Follow applicable procedures for receiving, handling, administration, and disposal.

MIMS Class

Cytotoxic Chemotherapy

ATC Classification

L01AA05 - chlormethine ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.

References

Anon. Mechlorethamine Hydrochloride. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 30/08/2024.

Brayfield A, Cadart C (eds). Chlormethine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 30/08/2024.

Chlormethine [Mechlorethamine] (Topical). UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 30/08/2024.

Joint Formulary Committee. Chlormethine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 30/08/2024.

Ledaga 160 micrograms/g Gel (Helsinn Birex Pharmaceuticals Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 30/08/2024.

Valchlor Gel (Helsinn Therapeutics [U.S.], Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 30/08/2024.

Disclaimer: This information is independently developed by MIMS based on Chlormethine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com