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Cardiovascular risks: NSAIDs can cause an increased risk of serious cardiovascular thrombosis, myocardial infarction and stroke which can be fatal. These risks increase with the duration of use. Patients with cardiovascular disease or who have risk factors for cardiovascular disease. (See Precautions.)
CAPTOFEN is contraindicated for the treatment of perioperative pain in coronary bypass surgery. (See Precautions.)
Gastrointestinal tract risks: NSAIDs cause an increased risk of serious side effects in the gastrointestinal tract, including bleeding, ulceration, and perforation of the stomach or intestine, which can be fatal. These side effects can occur at any time, without warning symptoms. Elderly patients have greater risk for serious side effects in the gastrointestinal tract. (See Precautions.)
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