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Vaccinations with live organism vaccines are not recommended in immunocompromised individuals (see Precautions).
Nalidixic acid together with high-dose Alkeran IV has caused deaths in children due to haemorrhagic enterocolitis.
Impaired renal function has been described in bone marrow transplant patients who were conditioned with high-dose Alkeran IV and who subsequently received cyclosporin to prevent graft-versus-host disease.
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