Adacel Drug Interactions

Vaccine-Drug Interactions: Immunosuppressive treatments may interfere with the development of the expected immune response. (See PRECAUTIONS).
Concomitant Vaccine Administration: ADACEL may be administered concurrently with a dose of trivalent inactivated influenza vaccine and with a dose of hepatitis B vaccine in 11 to 12 years old.
The concomitant use of ADACEL and trivalent inactivated influenza vaccine was evaluated in a clinical trial involving 696 adults 19 to 64 years of age. Booster response rates for diphtheria were non inferior when ADACEL was administered concurrently with influenza vaccine compared to separate administration. Although tetanus booster responses rates did not meet the non inferiority criterion, greater than 98% of participant in both groups achieved seroprotective levels of ≥ 0.1 IU/mL. Post vaccination pertussis antibody GMCs for both vaccine groups were robust, and non inferiority was achieved for PT, FHA and FIM. For PRN, the lower limit of the 90% CI of the GMC ratio was slightly lower (0.61) as compared to the non inferiority criterion.
Vaccines administered simultaneously should be given using separate syringes at separate injection sites and preferably in separate limbs. ADACEL should not be mixed in the same syringe with other parenterals.