Hepatocellular Carcinoma Disease Summary

Overview

Hepatocellular carcinoma (HCC) is a malignancy that originates from the liver.
It is usually asymptomatic for much of its natural history, however, symptoms such as jaundice, anorexia, weight loss, malaise and upper abdominal pain are seen in more advanced cases. 
Diagnosis of HCC is established by fulfilling the criteria of the 2018 American Association for the Study of Liver Diseases (AASLD) guidelines based on the Liver Imaging Reporting and Data System (LI-RADS).
Once the diagnosis of HCC is established, tumor burden, liver function and reserve, and the general health of the patient and presence of comorbidities influence the workup, treatment staging, and treatment options.

For further information regarding the management of Hepatocellular Carcinoma, please refer to Disease Algorithm for the Treatment Guideline.