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Add 19 mL of sterile water for injection to the vial, immediately shake the vial for 30 seconds. After allowing to stand for 2 to 3 minutes, it should be confirmed if the solution in the vial is clear (concentration: 5 mg/mL). If the contents of the vial are not completely dissolved, repeat to shake the vial and allow the contents to settle.
Visually confirm if there are no defect on vial closure system and no particulates in the solution. Do not use if any defects or particulates are observed.
After reconstitution with sterile water for Injection, the diluted solution should be used within 4 hours at 20 to 25℃ or within 24 hours at 2 to 8℃.
For adults and pediatrics with body weight ≥40 kg, 2 vials should be used for the administration on Day 1 (remdesivir 200 mg), and 20 mL each from each vial (40 mL in total) should be added to saline to make the total volume 100 mL or 250 mL. For the administration from Day2 (remdesivir 100 mg), 20 mL from 1 vial should be added to saline to make the total volume 100 mL or 250 mL. For pediatrics with body weight between 3.5 kg and <40 kg, dose should be adjusted according to Tables 8 and 9.
To mix, gently invert the infusion bag approximately 20 times, but avoid shaking.
After addition saline, any solution has been stored for >24 hours at 20-25°C or for >48 hours at 2-8°C, including the time after dissolution in water for injection, should be discarded without use. (See Tables 13 and 14.)
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Click on icon to see table/diagram/imagePrecautions Concerning Administration of the Drug: The drug should not be administered simultaneously with other drugs. Compatibility with anything other than saline is unknown.
Since VEKLURY does not contain preservatives, any unused reconstituted solution after preparation and any residue reconstituted solution after preparation should be discarded.
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