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Teclistamab is a humanised immunoglobulin G4-proline, alanine, alanine (IgG4-PAA) bispecific antibody directed against the B cell maturation antigen (BCMA) and CD3 receptors, produced in a mammalian cell line (Chinese hamster ovary [CHO]) using recombinant DNA technology.
The solution is colourless to light yellow, with a pH of 5.2 and osmolarity of approximately 296 mOsm/L (10 mg/mL solution for injection), and approximately 357 mOsm/L (90 mg/mL solution for injection).
TECVAYLI Solution for Injection 30 mg/3 mL: One 3 mL vial contains 30 mg of teclistamab (10 mg/mL).
TECVAYLI Solution for Injection 153 mg/1.7 mL: One 1.7 mL vial contains 153 mg of teclistamab (90 mg/mL).
Excipients/Inactive Ingredients: EDTA disodium salt dihydrate, Glacial acetic acid, Polysorbate 20 (E432), Sodium acetate trihydrate, Sucrose, Water for injections.
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