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No adverse effects were seen in rats given a single dose of 1000 μg/kg or in monkeys after repeated administration of romiplostim at 500 μg/kg (100 or 50 times the maximum clinical dose of 10 μg/kg, respectively).
In the event of overdose, platelet counts may increase excessively and result in thrombotic/thromboembolic complications. If the platelet counts are excessively increased, discontinue Romiplate and monitor platelet counts. Reinitiate treatment with Romiplate in accordance with dosing and administration recommendations (see Dosage & Administration and Precautions).
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