Rocuronium Bromide Main Life Dosage/Direction for Use

The standard dose for intubation of adults is 0.6 mg/kg of rocuronium bromide intravenously, and maintenance doses of 0.1 - 0.2 mg/kg may be added during surgery as needed. In the case of continuous infusion, initial rate should be 7 μg/kg/minute. Doses may be varied according to age and symptoms, however maximum intubation dosage is 0.9 mg/kg.
Administration to elderly: While monitoring the patient's condition, carefully administer at intubation dose of 0.6 mg/kg. If additional doses are given during surgery, determine the dose taking into consideration the duration of action of the intubation dose. When a different rocuronium bromide preparation was administered at 0.6 mg/kg, the elderly had about 16% reduced clearance compared with non-elderly (elderly: 3.45 mL/min/kg, non-elderly: 4.11 mL/min/kg) and the duration of action in elderly was 1.5 times longer compared to non-elderly (elderly: 42.4 minutes, non-elderly: 27.5 minutes).
Administration to paediatrics: Safety for neonates has not been established [Limited clinical experience]. Exercise caution when administering to neonates, infants and children. The onset of action is fast, and duration of action is short.