Do not use in patients with a history of hypersensitivity to streptococcal proteins, as the product may contain trace amounts of such material.
Do not use in patients with severe allergies manifested by a history of anaphylaxis or history or presence of multiple severe allergies.
Restylane Defyne/Restylane Kysse/Restylane Refyne/Restylane Volyme: Do not use in patients with known hypersensitivity to lidocaine or to amide-type local anaesthetics.