Pencla Duo

Acute bacterial sinusitis, cystitis, pyelonephritis, cellulitis, animal bites, severe dental abscess w/ spreading cellulitis in adults & childn.

As directed by physician.

Discontinue therapy in case of allergic reaction; acute generalised exanthematous pustulosis; antibiotic-associated colitis. Consider previous hypersensitivity reactions to penicillins, cephalosporins or other β-lactam agents before initiating therapy. May not be suitable when there is a high risk that the pathogens have reduced susceptibility or resistance to β-lactam agents not mediated by β-lactamases susceptible to inhibition by clavulanic acid (eg, penicillin-insusceptible S. pneumoniae). Convulsions may occur in patients w/ impaired renal function or in those receiving high doses. Avoid use if infectious mononucleosis is suspected. Concomitant use w/ allopurinol can increase the likelihood of allergic skin reactions. Prolonged use may result in an overgrowth of non-susceptible organisms. Hepatic problems have been reported predominantly in males & elderly patients, & may be associated w/ prolonged treatment. Periodically assess organ system functions (including renal, hepatic & haematopoietic function) during prolonged therapy. Appropriately monitor when anticoagulants are prescribed concomitantly. Take adequate fluids & monitor urinary output to reduce the possibility of amoxicillin crystalluria during administration of high amoxicillin doses. Use enzymatic glucose oxidase methods when testing for presence of glucose in urine during treatment w/ amoxicillin; false +ve results may occur w/ non-enzymatic methods. Clavulanic acid can cause non-specific binding of IgG & albumin by red cell membranes leading to false +ve Coombs test. Reports of +ve test results w/ Bio-Rad Laboratories Platelia Aspergillus EIA test in patients who were subsequently found to be free of Aspergillus infection. Caution in patients w/ evidence of hepatic impairment. Adjust dose according to degree of impairment in patients w/ renal impairment. Avoid use during pregnancy unless considered essential. Should only be used during breast-feeding if benefit/risk assessment to infant is considered.

Penicillins

J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

A