Short-term use, adverse effects may occur are hypersensitivity reactions; non-specific allergic reactions and anaphylaxis, respiratory tract reactivity e.g., asthma, aggravated asthma, bronchospasm, dyspnea; various skin reactions e.g., pruritus, urticarial, angioedema and more rarely exfoliative and bullous dermatoses (including epidermal necrolysis and erythema multiforme).
In the treatment of chronic conditions, under long-term treatment, additional adverse effects may occur such as hypersensitivity reactions with urticaria and pruritus, abdominal pain, nausea, dyspepsia, headache, acute renal failure, papillary necrosis, especially in long-term use, associated with increased serum urea and oedema, various skin rashes.