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Hypersensitivity to the active substances or to any of the excipients listed in Description.
Odefsey should not be co-administered with medicinal products that can result in significant decreases in rilpivirine plasma concentrations (due to cytochrome P450 [CYP]3A enzyme induction or gastric pH increase), which may result in loss of therapeutic effect of Odefsey (see Interactions), including: Carbamazepine, oxcarbazepine, phenobarbital, phenytoin; Rifabutin, rifampicin, rifapentine; Omeprazole, esomeprazole, dexlansoprazole, lansoprazole, pantoprazole, rabeprazole; Dexamethasone (oral and parenteral doses), except as a single dose treatment; St. John's wort (Hypericum perforatum).
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