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Drugs that affect testosterone: Barbiturates and other enzyme inducers: Interactions can occur with drugs that induce microsomal enzymes which can result in increased clearance of testosterone.
Effects of androgens on other drugs: Oxyphenbutazone: Increased oxyphenbutazone serum levels have been reported.
Oral anticoagulants: Testosterone and its derivatives have been reported to increase the activity of oral coumarin-based anticoagulants. Patients receiving oral anti-coagulants required close monitoring, especially at the beginning or end of androgen therapy. Increased monitoring of the prothrombin time, and INR determinations, are recommended.
Hypoglycaemics: Androgens may enhance the blood sugar reducing effects of insulin. Therefore, the dosage of hypoglycaemic agents may need to be lowered.
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