Minirin Overdosage

Tablet/Melt oral lyophilisate: Toxicity: Overdosage leads to prolonged duration of action with an increased risk of fluid retention and hyponatraemia. Even normal doses may in combination with considerable fluid intake cause water intoxication. Doses from 0.3 mcg/kg i.v. and 2.4 mcg/kg intranasally have caused hyponatraemia and convulsions in children and adults. On the other hand, 40 mcg intranasally administered to a 5-month-old baby and 80 mcg intranasally to a 5-year-old gave no symptoms. 4 mcg administered parenterally to a newborn caused oliguria and weight gain.
Symptoms: The same symptoms as for water intoxication. Headache, nausea. Fluid retention, hyponatraemia, hypoosmolality, oliguria, CNS depression, convulsions, pulmonary oedema. See also Adverse Reactions described in the text.
Treatment: The treatment of hyponatraemia should be individual but the following general recommendations may be given: Hyponatraemia is treated by interrupting the desmopressin treatment and fluid restriction. If the patient has symptoms an infusion of isotonic or hypertonic sodium chloride may be given. When the fluid retention is serious (convulsions and loss of consciousness) furosomide treatment is given.
Solution for injection: Overdose of MINIRIN solution for injection can lead to water retention and hyponatremia.
Treatment: Although the treatment of hyponatremia should be individualized, the following general recommendations can be given. Asymptomatic hyponatremia is treated with discontinuation of desmopressin treatment and fluid restriction. Infusion of isotonic or hypertonic sodium chloride may be added in cases with symptoms. When the fluid retention is severe (convulsions and unconsciousness) treatment with furosemide should be added.