M-M-R II Dosage/Direction for Use

For Intramuscular or Subcutaneous administration only.
Dose and Schedule: A single dose of M-M-R II is 0.5 mL.
The first dose is administered at 12 to 15 months of age. A second dose is administered at 4 to 6 years of age.
The second dose may be administered prior to 4 years of age, provided that there is a minimum interval of one month between the doses of measles, mumps and rubella virus vaccine, live.
Children who received an initial dose of measles, mumps and rubella vaccine prior to their first birthday should receive additional doses of vaccine at 12-15 months of age and at 4-6 years of age to complete the vaccination series [see Pharmacology: Clinical Studies: Immunogenicity under Actions].
For post-exposure prophylaxis for measles, administer a dose of M-M-R II vaccine within 72 hours after exposure.
Administration: Sterile Diluent Prefilled Syringe: To reconstitute, use the sterile diluent prefilled syringe supplied with the vaccine since it does not contain preservatives or other antiviral substances which might inactivate the vaccine viruses.
Attach a needle to the prefilled syringe.
Reconstitute the vaccine by slowly injecting the entire volume of sterile diluent contained in the prefilled syringe into the lyophilized vaccine vial. Gently agitate to dissolve completely. Discard if the lyophilized vaccine cannot be dissolved.
If two needles are provided: use one needle to reconstitute the vaccine and the other for its administration to the person to be vaccinated.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Visually inspect the vaccine before and after reconstitution prior to administration. Before reconstitution, the lyophilized vaccine is a light yellow compact crystalline plug. M-M-R II, when reconstituted, is a clear yellow liquid. Do not use the reconstituted vaccine if particulates are present or if it appears discolored.
Withdraw and administer the entire volume of the reconstituted vaccine.
Administer M-M-R II immediately after reconstitution. If not used immediately, the reconstituted vaccine may be stored between 36°F to 46°F (2°C to 8°C), protected from light, for up to 8 hours. Discard reconstituted vaccine if it is not used within 8 hours.