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The recommended oral dose of INTELENCE tablets is 200 mg (two 100 mg tablets) taken twice daily following a meal [see Pharmacology: Pharmacokinetics: Effects of Food on Oral Absorption under Actions]. The type of food does not affect the exposure to etravirine.
Method of Administration: Patients should be instructed to swallow the INTELENCE tablet(s) whole with a liquid such as water. Patients who are unable to swallow INTELENCE tablet(s) whole may disperse the tablet(s) in a glass of water.
The patient should be instructed to do the following: Place the tablet(s) in 5 ml (1 teaspoon) of water, or at least enough liquid to cover the medication.
Stir well until the water looks milky.
If desired, add more water or alternatively orange juice or milk (patients should not place the tablets in orange juice or milk without first adding water). The use of grapefruit juice or warm (greater than 40°C) or carbonated beverages should be avoided.
Drink it immediately.
Rinse the glass several times with water, orange juice, or milk and completely swallow the rinse each time to make sure the patient takes the entire dose.
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