Hyper Hep B Special Precautions

Hepatitis B immune globulin (human) should not be administered IV because of the potential for serious reactions. Injections should be made IM, and care should be taken to draw back on the plunger of the syringe before injection in order to be certain that the needle is not in a blood vessel.
IM injections are preferably administered in the anterolateral aspects of the upper thigh and the deltoid muscle of the upper arm. The gluteal region should not be used routinely as an injection site because of the risk of injury to the sciatic nerve. An individual decision as to which muscle is injected must be made for each patient based on the volume of material to be administered. If the gluteal region is used when very large volumes are to be injected or multiple doses are necessary, the central region must be avoided; only the upper, outer quadrant should be used.
Laboratory Tests: None required.
Use in pregnancy: Pregnancy Category C: Animal reproduction studies have not been conducted with Hyper Hep B. It is also not known whether Hyper Hep B can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Hyper Hep B should be given to a pregnant woman only if clearly needed.
Use in children: Safety and effectiveness in the pediatric population have not been established.