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Microbiology: Biclotymol has bacteriostatic and bactericidal properties particularly against gram-positive bacteria. It was found to have fungistatic activity (dermatophyte fungi, blastomyces, histoplasma, paracoccidioides) and anti-inflammatory and analgesic effects.
Pharmacokinetics: Absorption through buccal and oropharyngeal mucosa is very slow.
Toxicology: Preclinical Safety Data: Biclotymol LD50 following oral administration in the rat was found to be 11 g/kg and >10 g/kg in the mouse. No abnormal behaviour and no mortality were noticed in the rat with administrations of Hexaspray via the digestive tract using an oesophageal tube during 45 days and in the beagle dog by spraying on the pharyngeal mucosa the equivalent of 4-20 therapeutic doses.
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