Gilenya Contraindications

Immunodeficiency syndrome.
Patients with increased risk for opportunistic infections, including immunocompromised patients (including those currently receiving immunosuppressive therapies or those immunocompromised by prior therapies).
Severe active infections, active chronic infections (hepatitis, tuberculosis).
Active malignancies.
Severe liver impairment (Child-Pugh class C).
Patients who in the previous 6 months had myocardial infarction (MI), unstable angina pectoris, stroke/transient ischaemic attack (TIA), decompensated heart failure (requiring inpatient treatment), or New York Heart Association (NYHA) class III/IV heart failure (see Precautions).
Patients with severe cardiac arrhythmias requiring antiarrhythmic treatment with class Ia or class III antiarrhythmic medicinal products (see Precautions).
Patients with second-degree Mobitz type II atrioventricular (AV) block or third-degree AV block, or sick-sinus syndrome, if they do not wear a pacemaker (see Precautions).
Patients with a baseline QTc interval ≥500 msec (see Precautions).
During pregnancy and in women of childbearing potential not using effective contraception (see Precautions and Use in Pregnancy & Lactation).
Hypersensitivity to the active substance or to any of the excipients listed in Description.