Enablex Special Precautions

ENABLEX should be administered with caution to patients with autonomic neuropathy, hiatus hernia, clinically significant bladder outflow obstruction, risk for urinary retention, severe constipation or gastrointestinal obstructive disorders, such as pyloric stenosis.
ENABLEX should be used with caution in patients being treated for narrow-angle glaucoma (see Contraindications).
Other causes of frequent urination (heart failure or renal disease) should be assessed before treatment with ENABLEX. If urinary tract infection is present, an appropriate antibacterial therapy should be started.
ENABLEX should be used with caution in patients with risk of decreased gastrointestinal motility, gastro-oesophageal reflux and/or who are concurrently taking medicinal products (such as oral bisphosphonates) that can cause or exacerbate oesophagitis.
Safety and efficacy have not yet been established in patients with a neurogenic cause for detrusor overactivity.
Effects on ability to drive and use machines: No studies of the effects of ENABLEX on the ability to drive and use machines have been performed. As with other antimuscarinic agents, caution should be exercised when driving or using machines due to possible occurrence of undesirable effects such as abnormal vision, dizziness, insomnia and somnolence. For ENABLEX, these side effects have been reported to be uncommon.