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At present, the possible harm due to an overdose of this product is still unclear. In the early dose-finding clinical studies of this product, some patients with solid tumors took 6mg of fruquintinib daily, and it was observed that the dose-limiting toxicity under the dose was hand-foot skin reaction and asthenia. In the Phase II, III clinical studies of metastatic colorectal cancer, it was found that only individual patients had single drug overdose event (the maximum dose was 10mg/day), but no significant abnormal clinical manifestations occurred.
There are no specific antidotes for overdose of this product. In the event of suspected drug overdose, this product must be discontinued immediately and the patient should be closely monitored. Adopt the best supportive care when necessary.
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