Elaprase Caution For Usage

Preparation Instructions: Elaprase should be prepared and administered by a healthcare professional using aseptic techniques.
Determine the total volume of Elaprase to be administered and the number of vials needed based on the patient's weight and the recommended dose of 0.5 mg/kg, as illustrated on the formula as follows.

Click on icon to see table/diagram/image

Round-up to the next whole vial to determine the total number of whole vials needed from which to withdraw the calculated volume of Elaprase to be administered. Remove the required number of vials from the refrigerator to allow them to reach room temperature.
Before withdrawing the Elaprase solution from the vial, perform a visual inspection of each vial for particulate matter and discoloration. Elaprase is a clear to slightly opalescent, colorless solution. Do not use if the solution in the vial is discolored or particulate matter is present. Elaprase should not be shaken.
Withdraw the calculated volume of Elaprase from the appropriate number of vials.
Dilute the total calculated volume of Elaprase in sodium chloride 0.9% injection 100 mL. Once diluted into normal saline, the solution in the infusion bag should be mixed gently, but not shaken.
Elaprase is supplied in single-use vials. Remaining Elaprase left in a vial after withdrawing the patient's calculated dose should be disposed of in accordance with local requirements.