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Pregnancy: There are no or limited amount of data from the use of mebeverine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity (see Pharmacology: Toxicology: Preclinical safety data under Actions). Use of Duspatalin retard is advised against during pregnancy.
Breast-feeding: It is unknown whether mebeverine or one of its metabolites is excreted in human milk. Excretion of mebeverine in breast milk has not been investigated in animals. Duspatalin Retard should not be used during breast-feeding.
Fertility: No clinical data are available on the fertility in men or women; however, animal studies do not indicate damaging effects from Duspatalin Retard (see Pharmacology: Toxicology: Preclinical safety data under Actions).
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