Adult: As 0.05% cream or ointment: Apply thinly onto the affected areas 1-3 times daily depending on the severity of the condition.
Special Precautions
Not indicated for the treatment of rosacea or perioral dermatitis. Pregnancy and lactation.
Adverse Reactions
Significant: Hypercortisolism or HPA axis suppression (particularly in children or at high doses for prolonged periods), immunosuppression (prolonged use), systemic effects (e.g. manifestations of Cushing's syndrome, hyperglycaemia, glycosuria), Kaposi's sarcoma (prolonged use), subcapsular cataracts, increased intraocular pressure, glaucoma with possible nerve damage, local skin reactions (e.g. atrophy, striae, telangiectasias, burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, miliaria) following long-term use or use of occlusive dressings. Skin and subcutaneous tissue disorders: Hypertrichosis.
Do not apply on the face, eyes, mucous membranes, intertriginous areas, occluded or broken skin, and into a large surface area. Do not use occlusive dressings unless directed by the doctor.
Monitoring Parameters
Monitor for signs and symptoms of adrenal suppression, particularly with extensive or prolonged use; consider ACTH stimulation test, morning plasma cortisol test, and urinary free cortisol test. Assess for signs and symptoms of skin changes, vision changes, and hyperglycaemia.
Action
Description: Mechanism of Action: Diflorasone diacetate is a corticosteroid with high range of potency. It has anti-inflammatory, antipruritic, and vasoconstrictive properties. The exact mechanism by which topical corticosteroids exert their anti-inflammatory effect is not fully understood; however, it appears to involve the induction of phospholipase A2 inhibitory proteins (lipocortins), which sequentially inhibits the release of arachidonic acid, thereby suppressing the formation, release, and activity of endogenous inflammatory mediators (e.g. kinins, histamine, liposomal enzymes, prostaglandins). Pharmacokinetics: Absorption: Absorbed percutaneously; increased absorption with occlusive dressing. Metabolism: Metabolised in the liver.
Chemical Structure
Diflorasone Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 71415, Diflorasone. https://pubchem.ncbi.nlm.nih.gov/compound/Diflorasone. Accessed Aug. 27, 2025.
D07AC10 - diflorasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
References
Brayfield A, Cadart C (eds). Diflorasone Diacetate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/08/2025.Diflorasone Diacetate Cream (Emerald Therapeutics, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 04/08/2025.Diflorasone Diacetate Ointment (Sun Pharmaceutical Industries, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 04/08/2025.Diflorasone Diacetate. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 04/08/2025.Diflorasone. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 04/08/2025.
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