CoPlavix Contraindications

Due to the presence of both components of the medicinal product, CoPlavix is contraindicated in case of: Hypersensitivity to the active substances or to any of the excipients listed in Description; Severe hepatic impairment; Active pathological bleeding such as peptic ulcer or intracranial haemorrhage.
In addition, due to the presence of ASA, its use is also contraindicated in: Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) and syndrome of asthma, rhinitis, and nasal polyps; Patients with pre-existing mastocytosis, in whom the use of acetylsalicylic acid may induce severe hypersensitivity reactions (including circulatory shock with flushing, hypotension, tachycardia and vomiting); Severe renal impairment (creatinine clearance <30 ml/min); Third trimester of pregnancy (see Use in Pregnancy & Lactation); History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy; Active, or history of recurrent peptic ulcer/haemorrhage.