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Symptoms: There is limited clinical experience with brivaracetam overdose in humans. Somnolence and dizziness have been reported in a healthy subject taking a single dose of 1,400 mg of brivaracetam.
Film-coated tablet / Oral solution: The following adverse reactions were reported with brivaracetam overdose: nausea, vertigo, balance disorder, anxiety, fatigue, irritability, aggression, insomnia, depression, and suicidal ideation in the post-marketing experience. In general, the adverse reactions associated with brivaracetam overdose were consistent with the known adverse reactions.
Management of overdose: There is no specific antidote for overdose with brivaracetam. Treatment of an overdose should include general supportive measures. Since less than 10% of brivaracetam is excreted in urine, haemodialysis is not expected to significantly enhance brivaracetam clearance (see Pharmacology: Pharmacokinetics under Actions).
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