Besifloxacin: Uses, Dosage, Side Effects and More

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Hong Kong prescribing information.

Generic Medicine Info

Indications and Dosage

Ophthalmic
Bacterial conjunctivitis

Adult: As 0.6% ophthalmic susp: Instil 1 drop into the affected eye(s) tid (given 4-12 hours apart) for 7 days.
Child: ≥1 year As 0.6% ophthalmic susp: Same as adult dose.

Contraindications

Hypersensitivity to besifloxacin or other quinolone antibiotics.

Special Precautions

Not intended for subconjunctival injection or direct administration into the anterior chamber of the eye. Children. Pregnancy and lactation.

Adverse Reactions

Significant: Fungal or bacterial superinfection (prolonged use), hypersensitivity reactions.
Eye disorders: Conjunctival hyperaemia, blurred vision, eye irritation, pain, or pruritus.
Nervous system disorders: Headache.

Pregnancy Category (US FDA)

Ophth: C

Patient Counseling Information

Avoid wearing contact lenses during treatment or if signs or symptoms of eye infection are present.

Action

Description:
Mechanism of Action: Besifloxacin is a fluoroquinolone antibacterial agent that prevents bacterial DNA synthesis by inhibiting DNA gyrase (an enzyme required for bacterial DNA replication, transcription, and repair) and topoisomerase IV (an enzyme needed for decatenation during bacterial cell division).
Pharmacokinetics:
Excretion: Elimination half-life: Approx 7 hours.

Chemical Structure

Storage

Store between 15-25°C. Protect from light.

MIMS Class

Eye Anti-Infectives & Antiseptics

ATC Classification

S01AE08 - besifloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.

References

Besifloxacin Hydrochloride. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 05/08/2025.

Besifloxacin. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 05/08/2025.

Besifloxacin. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 05/08/2025.

Besivance Ophthalmic Suspension, 0.6% (Bausch & Lomb [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 05/08/2025.

Besivance Suspension (Bausch & Lomb Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 05/08/2025.

Brayfield A, Cadart C (eds). Besifloxacin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/08/2025.

Disclaimer: This information is independently developed by MIMS based on Besifloxacin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com