Alverine: Uses, Dosage, Side Effects and More

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Hong Kong prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Dysmenorrhoea

Adult: For the symptomatic relief of primary dysmenorrhoea: 60-120 mg 1-3 times daily.
Child: ≥12 years Same as adult dose.

Oral
Gastrointestinal spasm

Adult: For the symptomatic relief of spastic functional gastrointestinal disturbances, including diverticular disease of the colon and irritable bowel syndrome: 60-120 mg 1-3 times daily.
Child: ≥12 years Same as adult dose.

What are the brands available for Alverine in Hong Kong?

Profenil
Spasmonal

Contraindications

Paralytic ileus, intestinal obstruction.

Special Precautions

Patient with nausea or vomiting, anorexia, weight loss, pallor, fatigue, fever, blood from the bowel, severe constipation, abnormal vaginal discharge or bleeding, and dysuria. Patients who have recently travelled abroad. Children. Pregnancy and lactation.

Adverse Reactions

Significant: CNS effects (e.g. dizziness), hepatic effects (e.g. ALT and AST elevations).
Gastrointestinal disorders: Nausea.
Hepatobiliary disorders: Hepatitis.
Immune system disorders: Anaphylaxis, hypersensitivity reaction.
Nervous system disorders: Headache.
Respiratory, thoracic and mediastinal disorders: Dyspnoea, wheezing.
Skin and subcutaneous tissue disorders: Pruritus, skin rash.

Patient Counseling Information

This drug may cause dizziness, if affected, do not drive or operate machinery.

Overdosage

Symptoms: Hypotension, atropine-like toxic effects. Management: Supportive treatment for hypotension. Manage atropine-like symptoms as for atropine poisoning.

Action

Description:
Mechanism of Action: Alverine is an antispasmodic agent. It has a direct action on the smooth muscle of the alimentary tract and uterus, without affecting the heart, blood vessels, or trachea.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-1.5 hours (para hydroxy alverine [PHA]).
Metabolism: Rapidly metabolised into PHA, the primary active metabolite; undergoes further conversion to form 2 secondary metabolites.
Excretion: Mainly via urine (as metabolites). Elimination half-life: 0.8 hours (alverine); 5.7 hours (PHA).

Chemical Structure

Storage

Store below 25°C. Protect from moisture.

MIMS Class

Antispasmodics

ATC Classification

A03AX08 - alverine ; Belongs to the class of other drugs used for functional bowel disorders.

References

Alverine Citrate 60 mg Capsules (Noumed Life Sciences Limited). MHRA. https://products.mhra.gov.uk. Accessed 05/05/2025.

Alverine. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 05/05/2025.

Brayfield A, Cadart C (eds). Alverine Citrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/05/2025.

Joint Formulary Committee. Alverine Citrate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/05/2025.

Disclaimer: This information is independently developed by MIMS based on Alverine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com