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Vaccinations with live organism vaccines are not recommended in immunocompromised individuals (see Precautions).
Nalidixic acid together with high‑dose intravenous ALKERAN has caused deaths in the paediatric population due to haemorrhagic enterocolitis.
In paediatric population, for the Busulfan-Melphalan regimen it has been reported that the administration of ALKERAN less than 24 hours after the last oral busulfan administration may influence the development of toxicities.
Impaired renal function has been described in bone marrow transplant patients who were pre‑conditioned with high dose intravenous ALKERAN and who subsequently received cyclosporin to prevent graft‑versus‑host disease.
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