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Adacel: Based on the results of concomitant use clinical studies, ADACEL can be administered concomitantly with any of the following vaccines: inactivated Influenza vaccine, Hepatitis B vaccine, Inactivated or Oral Poliomyelitis vaccine and recombinant Human Papillomavirus vaccine (see Adverse Reactions) according to local recommendations.
Separate limbs must be used for the site of injection of concomitant parenteral vaccines. Interaction studies have not been carried out with other vaccines, biological products, or therapeutic medications. However, in accordance with commonly accepted immunization guidelines, since ADACEL is an inactivated product it may be administered concomitantly with other vaccines or immunoglobulins at a separate injection site.
In the case of immunosuppressive therapy, refer to Precautions.
Adacel Polio: Vaccine-Drug Interactions: Immunosuppressive treatments may interfere with the development of the expected immune response (see Precautions).
Concomitant Vaccine Administration: ADACEL-POLIO may be administered concurrently with a dose of hepatitis B vaccine. Supportive data from a study conducted with ADACEL suggests that ADACEL-POLIO may be used concomitantly with trivalent influenza vaccine. ADACEL POLIO has been safely administered concomitantly with measles-mumps-rubella vaccine in non-controlled clinical studies in children 3 to 5 years of age. Data are not available on concomitant use of ADACEL-POLIO and varicella vaccine.
Administering the most widely used live and inactivated vaccines during the same patient visit has produced seroconversion rates and rates of adverse reactions similar to those observed when the vaccines are administered separately. Vaccines administered concomitantly should be given using separate syringes at separate sites. Simultaneous administration is suggested, particularly when there is concern that a person may not return for subsequent vaccination.
ADACEL-POLIO should not be mixed in the same syringe with other parenterals.
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