Intravenous Evaluation of pituitary growth hormone reserve
Adult: In patients where measurement of pituitary reserve for human growth hormone can be of diagnostic usefulness: As 10% arginine hydrochloride solution: 30 g as a single dose via IV infusion over 30 minutes. Max total dose: 30 g. Child: In patients where measurement of pituitary reserve for human growth hormone can be of diagnostic usefulness: As 10% arginine hydrochloride solution: <60 kg: 0.5 g/kg as a single dose via infusion over 30 minutes (Max total dose: 30 g); ≥60 kg: Same as adult dose.
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Thận trọng
Patient with electrolyte imbalance or anuria. Not intended for therapeutic use. Avoid extravasation. Renal and severe hepatic impairment. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Hypersensitivity reactions (including anaphylaxis); infusion-related reactions. Gastrointestinal disorders: Nausea, vomiting. General disorders and administration site conditions: Local venous irritation. Nervous system disorders: Headache, numbness. Renal and urinary disorders: Haematuria. Vascular disorders: Flushing.
Monitor acid-base status (e.g. arterial or capillary blood gases); serum electrolytes (e.g. sodium, potassium, chloride, bicarbonate, phosphorus), BUN, glucose, plasma amino acids and ammonia. Assess for signs of infusion site reactions.
Quá liều
Symptoms: Transient metabolic acidosis with hyperventilation, cerebral oedema and hypotension. Management: Give a calculated dose of alkalising agent for persistent metabolic acidosis.
Tương tác
May increase the hypotensive effect of blood pressure-lowering agents. Estrogens and estrogen-progestin oral contraceptives may increase growth hormone response to arginine.
Tác dụng
Description: Mechanism of Action: Arginine, a dibasic amino acid, stimulates the pituitary release of growth hormone and prolactin through origins in the hypothalamus resulting in an increase in growth hormone in the plasma level. This increase is diminished or absent in patients with impaired pituitary function. Pharmacokinetics: Absorption: Time to peak plasma concentration: 22-30 minutes. Distribution: Crosses the placenta. Volume of distribution: Approx 33 L/kg. Metabolism: Extensively metabolised in the liver and intestines. Excretion: Via urine (16% during the 1st 90 minutes; biphasic elimination). Elimination half-life: 42 ± 2 minutes.
Đặc tính
Arginine Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 6322, Arginine. https://pubchem.ncbi.nlm.nih.gov/compound/Arginine. Accessed June 27, 2025.
Arginine Hydrochloride. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 02/06/2025.Arginine. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 02/06/2025.Brayfield A, Cadart C (eds). Arginine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/06/2025.R-gene Injection, Solution (Pharmacia & Upjohn Company LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/06/2025.
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