Aprindine

Advanced heart failure, severe conduction disturbances, parkinsonism, convulsive disorders.

Bradycardia, hypotension, hepatic or renal impairment. Perform blood and LFT during therapy.

Tremor, vertigo, ataxia, diplopia, memory impairment, hallucinations, convulsions; nausea, vomiting, bloating, hepatitis, cholestatic jaundice.
Potentially Fatal: Agranulocytosis.

Amiodarone.

Description:
Mechanism of Action: Aprindine is a class Ib antiarrhythmic agent which directly interferes with depolarisation of the cell membrane by blocking the fast inward current of Na into cardiac cells. It has a limited effect on the rate of change of the depolarisation phase of the action potential, shortens the repolarisation phase and the QT interval and elevates the fibrillation threshold.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract.
Distribution: 85-95% bound to plasma proteins.
Excretion: Excreted in the urine and bile. Half-life: about 20-27 hr.

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