Amcinonide

Childn. Pregnancy and lactation.

Burning, itching, soreness, stinging, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin maceration and atrophy, striae, miliaria; HPA axis and growth suppression, Cushing’s syndrome, hyperglycaemia, glucosuria.

Topical: C

Do not use on the face, groin, or axilla. Avoid use of occlusive dressings in the presence of infected or weeping lesions.

Perform urinary free cortisol and ACTH stimulation tests to monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression if drug is applied to a large surface area or under an occlusive dressing.

May diminish the therapeutic effect of aldesleukin, corticorelin and hyaluronidase. May enhance the hyperglycaemic effect of ceritinib. May increase the adverse/toxic effect of deferasirox.

Description:
Mechanism of Action: Amcinonide, a synthetic fluorinated glucocorticoid, has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces phospholipase A₂ inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release, and activity of endogenous chemical mediators of inflammation.
Pharmacokinetics:
Absorption: Adequately absorbed through intact skin and increases w/ inflammation/occlusion.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.

Source: National Center for Biotechnology Information. PubChem Database. Amcinonide, CID=443958, https://pubchem.ncbi.nlm.nih.gov/compound/Amcinonide (accessed on Jan. 20, 2020)

Store between 15-30°C. Do not freeze.

Corticoid dùng tại chỗ

D07AC11 - amcinonide ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.

Amcinonide Cream and Ointment (Taro Pharmaceuticals U.S.A., Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/09/2016.

Amcinonide Lotion (Fougera Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/09/2016.

Anon. Amcinonide (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/09/2016.

Buckingham R (ed). Amcinonide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/09/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Amcinonide (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 05/09/2016.