Alverine

Paralytic ileus, intestinal obstruction.

Patient with nausea or vomiting, anorexia, weight loss, pallor, fatigue, fever, blood from the bowel, severe constipation, abnormal vaginal discharge or bleeding, and dysuria. Patients who have recently travelled abroad. Children. Pregnancy and lactation.

Significant: CNS effects (e.g. dizziness), hepatic effects (e.g. ALT and AST elevations).
Gastrointestinal disorders: Nausea.
Hepatobiliary disorders: Hepatitis.
Immune system disorders: Anaphylaxis, hypersensitivity reaction.
Nervous system disorders: Headache.
Respiratory, thoracic and mediastinal disorders: Dyspnoea, wheezing.
Skin and subcutaneous tissue disorders: Pruritus, skin rash.

This drug may cause dizziness, if affected, do not drive or operate machinery.

Symptoms: Hypotension, atropine-like toxic effects. Management: Supportive treatment for hypotension. Manage atropine-like symptoms as for atropine poisoning.

Description:
Mechanism of Action: Alverine is an antispasmodic agent. It has a direct action on the smooth muscle of the alimentary tract and uterus, without affecting the heart, blood vessels, or trachea.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-1.5 hours (para hydroxy alverine [PHA]).
Metabolism: Rapidly metabolised into PHA, the primary active metabolite; undergoes further conversion to form 2 secondary metabolites.
Excretion: Mainly via urine (as metabolites). Elimination half-life: 0.8 hours (alverine); 5.7 hours (PHA).

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 3678, Alverine. https://pubchem.ncbi.nlm.nih.gov/compound/Alverine. Accessed May 27, 2025.

Store below 25°C. Protect from moisture.

Thuốc chống co thắt

A03AX08 - alverine ; Belongs to the class of other drugs used for functional bowel disorders.

Alverine Citrate 60 mg Capsules (Noumed Life Sciences Limited). MHRA. https://products.mhra.gov.uk. Accessed 05/05/2025.

Alverine. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 05/05/2025.

Brayfield A, Cadart C (eds). Alverine Citrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/05/2025.

Joint Formulary Committee. Alverine Citrate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/05/2025.