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Haemorrhagic episodes in patients with haemophilia A
Adult: As treatment and prophylaxis: Dosage is individualised based on the severity of factor VIII deficiency, extent and location of bleeding, and patient's clinical response. Recommended target factor VIII concentrations: Early haemarthrosis, muscle bleeding or oral bleeding: 20-40%; doses are given 12-24 hourly for at least 1 day until the bleeding episode, as indicated by pain, is resolved, or healing is attained. More extensive haemarthrosis, muscle bleeding or haematoma: 30-60%; doses are given 12-24 hourly for 3-4 days or more until pain and acute disability are resolved. Life-threatening haemorrhages: 60-100%; doses are given 8-24 hourly until threat is resolved. Minor surgery, including tooth extraction: 30-60%; doses are given 24 hourly for at least 1 day until healing is attained. Major surgery (pre-operative and post-operative): 80-100%; doses are given 8-24 hourly until adequate wound healing, then continue therapy for at least another 7 days to maintain factor VIII levels of 30-60%. Dosage is calculated based on a formula. Required units (international units) = body weight (kg) x desired factor VIII rise (%) x 0.5. Doses are given via inj over ≤5 min at a Max rate of 10 mL/min. Dosage and treatment recommendations may vary between countries (refer to specific local guidelines).
Child: As treatment and prophylaxis: Dosage is individualised based on the severity of factor VIII deficiency, extent and location of bleeding, and patient's clinical response. <6 years Recommended target factor VIII concentrations: Early haemarthrosis, muscle bleeding or oral bleeding: 20-40%; doses are given 8-24 hourly for at least 1 day until the bleeding episode, as indicated by pain, is resolved, or healing is attained. More extensive haemarthrosis, muscle bleeding or haematoma: 30-60%; doses are given 8-24 hourly for 3-4 days or more until pain and acute disability are resolved. Life-threatening haemorrhages: 60-100%; doses are given 6-12 hourly until threat is resolved. Minor surgery, including tooth extraction: 30-60%; doses are given 12-24 hourly for at least 1 day until healing is attained. Major surgery (pre-operative and post-operative): 80-100%; doses are given 6-24 hourly until adequate wound healing, then continue therapy for at least another 7 days to maintain factor VIII levels of 30-60%; ≥6 years Same as adult dose. Dosage is calculated based on a formula. Required units (international units) = body weight (kg) x desired factor VIII rise (%) x 0.5. Doses are given via inj over ≤5 min at a Max rate of 10 mL/min.
Child: As treatment and prophylaxis: Dosage is individualised based on the severity of factor VIII deficiency, extent and location of bleeding, and patient's clinical response. <6 years Recommended target factor VIII concentrations: Early haemarthrosis, muscle bleeding or oral bleeding: 20-40%; doses are given 8-24 hourly for at least 1 day until the bleeding episode, as indicated by pain, is resolved, or healing is attained. More extensive haemarthrosis, muscle bleeding or haematoma: 30-60%; doses are given 8-24 hourly for 3-4 days or more until pain and acute disability are resolved. Life-threatening haemorrhages: 60-100%; doses are given 6-12 hourly until threat is resolved. Minor surgery, including tooth extraction: 30-60%; doses are given 12-24 hourly for at least 1 day until healing is attained. Major surgery (pre-operative and post-operative): 80-100%; doses are given 6-24 hourly until adequate wound healing, then continue therapy for at least another 7 days to maintain factor VIII levels of 30-60%; ≥6 years Same as adult dose. Dosage is calculated based on a formula. Required units (international units) = body weight (kg) x desired factor VIII rise (%) x 0.5. Doses are given via inj over ≤5 min at a Max rate of 10 mL/min.
Intravenous
Prophylaxis in severe haemophilia A
Adult: For long-term prophylaxis of bleeding episodes: 20-40 international units/kg at intervals of 2-3 days. Alternatively, 20-40 international units/kg every other day (3-4 times weekly). Doses are given via inj over ≤5 min at a Max rate of 10 mL/min. Dosage and treatment recommendations may vary between countries (refer to specific local guidelines).
Child: There is limited information regarding the use of this drug in this population, treatment recommendations may vary between countries (refer to specific local guidelines).
Child: There is limited information regarding the use of this drug in this population, treatment recommendations may vary between countries (refer to specific local guidelines).
