K-Cab Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Tegoprazan

Indications/Uses

Erosive & non-erosive GERD; gastric ulcer. H. pylori eradication concurrently given w/ appropriate antibiotic therapy in patients w/ peptic ulcer &/or chronic atrophic gastritis.

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Dosage/Direction for Use

Adult Erosive & non-erosive GERD 50 mg once daily for 4 wk. Patient who does not heal or has persistent symptoms after 4 wk May consider additional 4-wk treatment. Gastric ulcer 50 mg once daily for 8 wk. H. pylori eradication in patients w/ peptic ulcer &/or chronic atrophic gastritis Tegoprazan 50 mg, clarithromycin 500 mg & amoxicillin 1 g bid for 7 days.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity to tegoprazan or substituted benzimidazoles. Concomitant use w/ atazanavir, nelfinavir or rilpivirine-containing products. Pregnancy & lactation.

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Special Precautions

May alleviate symptoms & delay diagnosis; exclude malignancy in the presence of any alarming symptoms (eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis or melena) & when gastric ulcer is suspected or present. Cyanocobalamin deficiency due to long-term therapy. Increased risk for osteoporosis-related fractures of hip, wrist, or spine in patients who received high-dose & long-term therapy; GI infections (eg, Salmonella, Campylobacter, Clostridium difficile) & Clostridium difficile-associated diarrhea especially in hospitalized patients. Tetany, arrhythmias & seizures. Monitor Mg levels prior to treatment initiation & periodically in patients expected to be on prolonged treatment or in concomitant use w/ digoxin or drugs that may cause hypomagnesemia eg, diuretics. Hepatic & renal impairment. Discontinue nursing during therapy. Elderly. Ped & adolescent patients.

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Use In Pregnancy & Lactation

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Adverse Reactions

Nausea, diarrhea, dyspepsia, upper abdominal pain, abdominal pain & distention; nasopharyngitis, viral URTI, cystitis; chest discomfort, asthenia; increased creatine phosphokinase; headache, dizziness, dysgeusia; urticaria, pruritus, erythema.

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Drug Interactions

Decreased absorption of drugs where gastric pH is important determinant of their bioavailability; ketoconazole, itraconazole, ampicillin ester, atazanavir, Fe salts, erlotinib, gefitinib & mycophenolate mofetil. Increased absorption of digoxin. Decreased plasma conc of atazanavir, nelfinavir or rilpivirine. Increased AUC_T w/ & of clarithromycin.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view K-Cab detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BC09 - tegoprazan ; Belongs to the class of potassium-competitive acid blocker. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Thai FDA Category

Presentation/Packing

Form

K-Cab FC tab 50 mg

Packing/Price

30's

K-Cab

Manufacturer:

HK inno.

Distributor:

Pacific Healthcare

Marketer:

Pacific Healthcare