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Chlorhexidine + Cetrimide


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Antiseptic and disinfectant
Adult: Chlorhexidine gluconate 0.015% and cetrimide 0.15% solution
Chlorhexidine gluconate 0.05% and cetrimide 0.5% solution
Chlorhexidine acetate 0.015% and cetrimide 0.15% solution
Chlorhexidine acetate 0.05% and cetrimide 0.5% solution
Chlorhexidine acetate 0.1% and cetrimide 1% solution
As undiluted solution: Apply onto the affected area(s) as needed.

Chlorhexidine gluconate 0.3% and cetrimide 3% liquid
For minor burns, cuts, wounds, sores and rashes: Dilute 10 mL liquid in 100 mL of water then apply to the affected area(s).

Chlorhexidine digluconate 0.1% and cetrimide 0.5% cream
To clean and prevent infection in all types of lesions (e.g. minor blisters, minor burns and small wounds): Apply onto the affected area(s).
What are the brands available for Chlorhexidine + Cetrimide in Thailand?
Other Known Brands
  • Bactricide
  • Clocimide Concentrate
  • Dekka
  • Dekkalon
  • Inhibac Hospital Conc
  • Killa
  • Septol-C
  • Septrex
See more
Incompatibility
Chlorhexidine: Incompatible with anionic substances (e.g. soap, toothpaste).
Contraindications
Hypersensitivity. Application to the eye, auditory canal, near the brain meninges or spinal cord.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Skin and subcutaneous tissue disorders: Dry skin, dermatitis, pruritus, erythema, eczema, rash, urticaria, skin irritation, blisters.
Potentially Fatal: Serious allergic reactions (e.g. anaphylactic shock).
Action
Description:
Mechanism of Action: Chlorhexidine is a cationic bisbiguanide antiseptic which exerts its bactericidal activity against Gram-positive and Gram-negative organisms by binding cationic molecules to negatively charged bacterial cell walls and extramicrobial complexes leading to precipitation of cytoplasmic contents of bacterial cell wall which results in cell death. At low concentrations, it acts as a bacteriostatic by alteration of bacterial cell osmotic equilibrium and leakage of potassium and phosphorus.
Cetrimide is a quaternary ammonium antiseptic with bactericidal action against Gram-positive and Gram-negative (at higher concentrations) bacteria, but ineffective against bacterial spores. It is effective against some viruses and has variable antifungal activity.
Pharmacokinetics:
Absorption: Poorly absorbed from the skin.
Chemical Structure

Chemical Structure Image
Chlorhexidine

Source: National Center for Biotechnology Information. PubChem Database. Chlorhexidine, CID=9552079, https://pubchem.ncbi.nlm.nih.gov/compound/Chlorhexidine (accessed on Jan. 21, 2020)


Chemical Structure Image
Cetrimide

Source: National Center for Biotechnology Information. PubChem Database. Cetrimide, CID=14250, https://pubchem.ncbi.nlm.nih.gov/compound/Cetrimide (accessed on Jan. 21, 2020)

Storage
Store below 25°C. Protect from light.
MIMS Class
Skin Antiseptics & Disinfectants
ATC Classification
D08AC52 - chlorhexidine, combinations ; Belongs to the class of biguanide and amidine antiseptics. Used in the treatment of dermatological diseases.
References
Anon. Chlorhexidine Gluconate (Topical). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 14/08/2024.

Baxter Healthcare Ltd. Chlorhexidine Acetate with Cetrimide, Antiseptic Solutions data sheet 20 October 2020. Medsafe. http://www.medsafe.govt.nz. Accessed 14/08/2024.

Brayfield A, Cadart C (eds). Cetrimide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/08/2024.

Brayfield A, Cadart C (eds). Chlorhexidine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/08/2024.

Cetrimide. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 14/08/2024.

Chlorhexidine and Cetrimide. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 14/08/2024.

Chlorhexidine Gluconate (Topical). UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 14/08/2024.

Joint Formulary Committee. Chlorhexidine with Cetrimide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/08/2024.

Rexom Wina Antiseptic Liquid (KCK Pharmaceutical Industries Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 14/08/2024.

RinsA CGC 15 Sterile Topical Antiseptic Solution (Ain Medicare Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 14/08/2024.

RinsA CGC 50 Sterile Topical Antiseptic Solution (Ain Medicare Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 14/08/2024.

Savlon Antiseptic Cream (Thornton & Ross Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 14/08/2024.

Sterets Tisept Sachets (Medlock Medical Ltd). MHRA. https://products.mhra.gov.uk. Accessed 14/08/2024.

Disclaimer: This information is independently developed by MIMS based on Chlorhexidine + Cetrimide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com
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