SC/IV Established cytotoxic chemotherapy Recommended dose: 0.5 MU/kg/day (5 mcg/kg/day). Administer 1st dose at least 24 hr after cytotoxic chemotherapy. Daily dosing w/ filgrastim should continue until expected neutrophil nadir is passed & neutrophil count has recovered to normal range.
Patient w/ myeloablative therapy followed by bone marrow transplantation Recommended starting dose: 1 MU/kg/day (10 mcg/kg/day). Administer 1st dose at least 24 hr following cytotoxic chemotherapy & at least 24 hr after bone marrow infusion.
SC PBPCs mobilisation Patient undergoing myelosuppressive or myeloablative therapy followed by autologous PBPC transplantation Recommended dose: 1 MU/kg/day (10 mcg/kg/day) for 5-7 consecutive days. Recommended dose (after myelosuppressive chemotherapy): 0.5 MU/kg/day (5 mcg/kg/day) from the 1st day after chemotherapy completion until expected neutrophil nadir is passed & neutrophil count has recovered to normal range.
Normal donor prior to allogeneic PBPC transplantation 1 MU/kg/day (10 mcg/kg/day) for 4-5 consecutive days.
Congenital neutropenia Recommended starting dose: 1.2 MU/kg/day (12 mcg/kg/day) as single dose or in divided doses.
Idiopathic or cyclic neutropenia Recommended starting dose: 0.5 MU/kg/day (5 mcg/kg/day) as single dose or in divided doses.
HIV patient Recommended starting dose: 0.1 MU/kg/day (1 mcg/kg/day) w/ titration up to a max of 0.4 MU/kg/day (4 mcg/kg/day) until normal neutrophil count is reached & can be maintained (ANC >2 x 10
9/L).
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