Patients w/ convincing IgE mediated asthma. Add-on therapy to improve asthma control in adult & adolescent (≥12 yr); child (6 to <12 yr) w/ severe persistent allergic asthma who have +ve skin test or
in vitro reactivity to perennial aeroallergen, frequent daytime symptoms or night-time awakenings, multiple documented severe asthma exacerbations despite daily high-dose inhaled corticosteroids + long-acting inhaled β
2-agonist; reduced lung function (FEV
1 <80%) (for adult & adolescent only). Add-on therapy to intranasal corticosteroids for chronic rhinosinusitis w/ nasal polyps (CRSwNP) in adult (≥18 yr) w/ inadequate response to intranasal corticosteroids. Add-on therapy for chronic spontaneous urticaria in adult & adolescent (≥12 yr) w/ inadequate response to H
1 antihistamine treatment.