Verzenio Dosage & Drug Information

Concise Prescribing Info

Contents

Abemaciclib

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Indications/Uses

In combination w/ endocrine therapy for the adjuvant treatment of adults w/ hormone receptor (HR) +ve, human epidermal growth factor receptor 2 (HER2) -ve, node +ve early breast cancer at high risk of recurrence. In combination w/ aromatase inhibitor as initial endocrine-based therapy for adults w/ HR +ve, HER2 -ve advanced or metastatic breast cancer. In combination w/ fulvestrant for adults w/ HR +ve, HER2 -ve advanced or metastatic breast cancer w/ disease progression following endocrine therapy.

Dosage/Direction for Use

150 mg bd in combination w/ fulvestrant, tamoxifen or aromatase inhibitor. Patient concomitantly taking strong CYP3A4 inhibitor 100 mg bd. Severe hepatic impairment Decrease dosing frequency to once daily.

Administration

May be taken with or without food: Take at the same time each day. Swallow whole, do not chew/crush/split. Avoid grapefruit or grapefruit juice.

Contraindications

Hypersensitivity.

MIMS Class

Targeted Cancer Therapy

ATC Classification

L01EF03 - abemaciclib ; Belongs to the class of cyclin-dependent kinase (CDK) inhibitors. Used in the treatment of cancer.

Regulatory Classification

POM

Presentation/Packing

Form

Verzenio FC tab 100 mg

Packing/Price

1's

Form

Verzenio FC tab 150 mg

Packing/Price

1's

Form

Verzenio FC tab 50 mg

Packing/Price

1's

Verzenio

abemaciclib

Manufacturer:

Lilly del Caribe