Unasyn Oral/Unasyn (IM/IV)

Oral: URTI including sinusitis, otitis media & tonsillitis; lower resp tract infections including bacterial pneumonia & bronchitis, UTI & pyelonephritis; skin & soft tissue infections & gonococcal infections. Inj: Upper & lower resp tract infections including sinusitis, otitis media & epiglottitis; bacterial pneumonia, UTI & pyelonephritis; intra-abdominal infections including peritonitis, cholecystitis, endometritis & pelvic cellulitis; bacterial septicemia; skin, soft tissue, bone & joint infections & gonococcal infections. Peri-op prophylaxis for reduction of post-op wound infections in patients undergoing abdominal or pelvic surgery & in termination of pregnancy or cesarean section.

Oral Adult (including elderly) & childn ≥30 kg 375-750 mg bd. Childn <30 kg 25-50 mg/kg daily in 2 divided doses depending on the severity of the infection. Uncomplicated gonorrhea 2.25 g as a single dose. Concomitant probenecid: 1 g to be administered in order to prolong plasma conc of Unasyn. Inj Adult 1.5-12 g daily in divided doses every 6-8 hr. Max: 4 g sulbactam daily. Mild infection 1.5-3 g daily. Moderate infection Up to 6 g daily. Severe infection Up to 12 g daily. Treatment is normally given for 5-14 days. Surgical infection prophylaxis 1.5-3 g at induction of anesth, may be repeated every 6-8 hr. Uncomplicated gonorrhea 1.5 g as a single dose. Administer w/ concomitant probenecid 1 g orally. Childn, infant, neonate Most infections 150 mg/kg daily every 6-8 hr. Neonate (1st wk of life) 75 mg/kg daily in divided doses every 12 hr.

May be taken with or without food.

History of allergic reaction to any penicillins.

Penicillins

J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

POM