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Indications/Uses
Essential HTN in adults. Risk reduction of non-fatal stroke or MI in patients ≥55 yr at high risk of developing major CV events who cannot tolerate ACE inhibitors. High risk of CV events including CAD evidence, peripheral arterial disease, stroke, transient ischemic attack, DM w/ end-organ damage evidence.
Dosage/Direction for Use
Essential HTN 40 mg once daily. May increase dose to a max of 80 mg once daily in cases where target BP is not achieved. CV morbidity reduction 80 mg once daily. Mild to moderate hepatic impairment Max: 40 mg once daily.
Administration
May be taken with or without food: Swallow whole w/ liqd
Contraindications
Hypersensitivity. Biliary obstructive disorders. Concomitant use w/ aliskiren in patients w/ DM or renal impairment (GFR <60 mL/min/1.73 m2). Rare hereditary conditions that may be incompatible w/ an excipient. Severe hepatic impairment. Pregnancy (2nd & 3rd trimesters). Lactation.