Tegretol/Tegretol CR

Monotherapy & combination therapy for epilepsy (except absence & myoclonic seizures). Acute mania & maintenance treatment of bipolar-affective disorders to prevent or attenuate recurrence. Alcohol w/drawal syndrome. Idiopathic trigeminal neuralgia & trigeminal neuralgia due to multiple sclerosis (typical or atypical). Idiopathic glossopharyngeal neuralgia. Painful diabetic neuropathy. Diabetes insipidus centralis. Polyuria & polydipsia of neurohormonal origin.

Adult Epilepsy Initially 100-200 mg once or bd, slowly raised to 400 mg bd-tds. Oral susp Max daily dose: 1,200 mg. Acute mania & maintenance treatment of bipolar-affective disorders Dosage range: 400-1,600 mg daily. Usual dosage: 400-600 mg daily in 2-3 divided doses. Oral susp Max daily dose: 1,200 mg. Alcohol w/drawal syndrome 200 mg tds, increased to 400 mg tds for 1st few days in severe cases. Trigeminal & glossopharyngeal neuralgia Initially 200-400 mg daily, slowly raised daily until freedom from pain is achieved (normally 200 mg tds-qds). Then gradually reduce dosage to lowest possible maintenance level. Max: 1,200 mg daily. Painful diabetic neuropathy 200 mg bd-qds. Diabetes insipidus centralis 200 mg bd-tds. Childn Epilepsy Maintenance dose: 10-20 mg/kg daily in divided doses, >4 yr Initially 100 mg daily, increase at wkly intervals by 100 mg, ≥4 wk to 4 yr Initially 20-60 mg daily, increasing by 20-60 mg every 2nd day. Max: >15 yr 1,200 mg daily, 6-15 yr 1,000 mg daily, ≥4 wk to 6 yr 35 mg/kg daily. Elderly ≥65 yr Trigeminal neuralgia Initially 100 mg bd, slowly raised daily until freedom from pain is achieved (normally 200 mg tds-qds). Then gradually reduce dosage to lowest possible maintenance level. Max: 1,200 mg daily.

Should be taken with food: Avoid grapefruit juice. CR tab: Swallow whole, do not chew/crush.

Hypersensitivity to carbamazepine or structurally related drugs (eg, TCAs). AV block. History of bone marrow depression & hepatic porphyrias (eg, acute intermittent or variegate porphyria, porphyria cutanea tarda). In combination w/ MAOIs. Neonates <4 wk.

Anticonvulsants / Drugs for Neuropathic Pain

N03AF01 - carbamazepine ; Belongs to the class of carboxamide derivatives antiepileptic.

POM