Tazocin

Lower resp tract, intra-abdominal, skin & skin structure infections; complicated & uncomplicated UTI; bacterial septicemia. Polymicrobial infections. Bacterial infections in neutropenic adults or childn in combination w/ aminoglycoside. Intra-abdominal infections including appendicitis complicated by rupture or abscess, peritonitis & biliary infections in hospitalized childn 2-12 yr.

IV Adult & childn >12 yr 4.5 g 8 hrly. Total daily dose: 2.25-4.5 g every 6-8 hr. Neutropenia 4.5 g 6 hrly in combination w/ aminoglycoside. Childn <12 yr weighing >50 kg Adult dose, <50 kg Adjusted dose: 90 mg/kg 6 hrly in combination w/ aminoglycoside. Intra-abdominal infection Hospitalized childn 2-12 yr weighing up to 40 kg 112.5 mg/kg 8 hrly, >40 kg 4.5 g 8 hrly. Renal insufficiency in adult & childn weighing >50 kg w/ CrCl 20-80 mL/min 4 g/500 mg 8 hrly in divided doses, <20 mL/min 4 g/500 mg 12 hrly in divided doses; <50 kg w/ CrCl 40-80 mL/min 90 mg/kg 6 hrly, 20-40 mL/min 90 mg/kg 8 hrly, <20 mL/min 90 mg/kg 12 hrly. Childn <50 kg on hemodialysis 45 mg/kg 8 hrly. Duration of therapy: Min: 5 days. Max: 14 days. All doses to be given by slow IV inj over at least 3-5 min or slow IV infusion over 20-30 min.

Hypersensitivity to β-lactams (including penicillins & cephalosporins) or β-lactamase inhibitors.

Penicillins

J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

POM