Struvir

HIV-infected adults & childn in combination w/ other antiretrovirals.

Adult, adolescent & childn weighing at least 25 kg 300 mg daily. May be administered as 150 mg bd or 300 mg once daily. Childn weighing ≥20 to <25 kg 225 mg daily. May be administered as either 75 mg in the morning & 150 mg in the evening or 225 mg once daily, 14 to <20 kg 150 mg daily. May be administered 75 mg bd or 150 mg once daily. Adult, adolescent & childn weighing at least 25 kg w/ CrCl 15-<30 mL/min 1st dose: 150 mg. Maintenance dose: 100 mg once daily, 5-<15 mL/min 1st dose: 150 mg. Maintenance dose: 50 mg once daily, <5 mL/min 1st dose: 50 mg. Maintenance dose: 25 mg once daily. Childn ≥3 mth & weighing <25 kg w/ CrCl ≥50 mL/min 1st dose: 5 mg/kg. Maintenance dose: 5 mg/kg bd, 30-<50 mL/min 1st dose: 5 mg/kg. Maintenance dose: 5 mg/kg once daily, 15-<30 mL/min 1st dose: 5 mg/kg. Maintenance dose: 3.25 mg/kg once daily; 5-<15 mL/min 1st dose: 5 mg/kg. Maintenance dose: 1.63 mg/kg once daily, <5 mL/min 1st dose: 1.63 mg/kg. Maintenance dose: 0.88 g/kg once daily.

May be taken with or without food: Swallow w/o crushing. May be crushed & added to a small amount of semi-solid food or liqd for patients unable to swallow tab.

Hypersensitivity.

Antivirals

J05AF05 - lamivudine ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.

POM