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Indications/Uses
Long-term enzyme replacement therapy in patients w/ ped-onset hypophosphatasia (HPP).
Dosage/Direction for Use
SC Perinatal/infantile-onset HPP 2 mg/kg tds wkly or 1 mg/kg 6 times wkly. May be increased to up to 3 mg/kg tds wkly for lack of efficacy (eg, no improvement in resp status, growth or radiographic findings). Juvenile-onset HPP 2 mg/kg tds wkly or 1 mg/kg 6 times wkly.