Rosuvastatin Sandoz

Primary hypercholesterolaemia & mixed dyslipidaemia (including Fredrickson type IIa, IIb & heterozygous familial hypercholesterolaemia) & primary dysbetalipoproteinaemia (Fredrickson type III hyper lipoproteinaemia) as an adjunct to diet when response to diet & exercise is inadequate. Homozygous familial hypercholesterolaemia either alone or as an adjunct to diet & other lipid-lowering treatments (eg, LDL apheresis). Primary prevention of CV disease (CVD); reduces risk of stroke, MI & arterial revascularization procedures in individuals w/o clinically evident CHD but w/ increased risk of CVD based on age ≥50 yr in men & ≥60 yr in women, hsCRP ≥2 mg/L & presence of at least 1 additional CVD risk factor (eg, HTN, low HDL-C, smoking or family history of premature CHD). Adjunct to diet to reduce total cholesterol, LDL-C & ApoB levels in adolescent boys & girls 10-17 yr who are at least 1 yr postmenarche, w/ heterozygous familial hypercholesterolaemia if after an adequate trial of diet therapy w/ findings eg, LDL-C >190 mg/dL or >160 mg/dL & +ve family history of premature CVD or ≥2 other CVD risk factors.

Individualized dosage. Statin naive patient or those who switched from another HMG CoA reductase inhibitor Initially 5 or 10 mg once daily. Patient w/ severe hypercholesterolaemia at high CV risk (particularly those w/ familial hypercholesterolaemia) & those who do not achieve their treatment goal on 20 mg May increase dose to 40 mg. Asian patient Consider initiation of therapy w/ 5 mg once daily. Max daily dose: 20 mg. Patient w/ c.521CC or c.421AA genotype Max: 20 mg once daily. Childn w/ heterozygous familial hypercholesterolemia Initially 5 mg once daily. Max daily dose: 10 mg.

May be taken with or without food.

Hypersensitivity. Concomitant use w/ cyclosporin. Active liver disease including unexplained, persistent elevations of serum transaminases. Severe renal impairment (CrCl <30 mL/min).

Dyslipidaemic Agents

C10AA07 - rosuvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.

POM