Premed w/ analgesic/antipyretic (eg, paracetamol) & antihistamine (eg, diphenhydramine) before each infusion; may consider premed w/ corticosteroids if not given in combination w/ glucocorticoid-containing chemotherapy for NHL.
IV infusion Low-grade or follicular NHL Adult Monotherapy: Initially 375 mg/m
2 once wkly for 4 wk. In combination w/ CVP chemotherapy: 375 mg/m
2 for 8 cycles (21 days/cycle) administered on day 1 of each cycle after corticosteroid IV. Re-treatment following relapse: 375 mg/m
2 once wkly for 4 wk.
Patient w/ previously untreated follicular lymphoma Maintenance: 375 mg/m
2 once every 2 mth (starting 2 mth after last dose of induction therapy) until disease progression. Max: 2 yr.
Relapsed/refractory follicular lymphoma Maintenance: 375 mg/m
2 once every 3 mth until disease progression. Max: 2 yr.
DLCL In combination w/ CHOP chemotherapy: 375 mg/m
2 on day 1 of each cycle after corticosteroid IV.
CLL 1st infusion: 375 mg/m
2 in the 1st cycle. Initial infusion rate: 50 mg/hr, may increase by 50 mg/hr increments every 30 min. Max: 400 mg/hr. Subsequent infusions: 500 mg/m
2 in cycles 2-6, in combination w/ FC, administered every 28 days. Infusion rate: 100 mg/hr may increase by 100 mg/hr increments every 30 min. Max: 400 mg/hr. Prophylaxis w/ adequate hydration & administer uricostatics 48 hr prior to start of therapy.
Patient w/ lymphocyte count >25 x 109/L Administer prednisone/prednisolone 100 mg IV shortly before Rixathon infusion.
RA 1,000 mg followed 2 wk later by 2nd 1,000 mg. Premed w/ methylprednisolone 100 mg IV 30 min prior to therapy. Alternative subsequent, faster, infusions schedule: 4 hr 15 min for the 1st infusion & 3 hr 15 min for the 2nd infusion. If patients did not experience serious infusion-related adverse event, initiate at a rate of 250 mg/hr for the 1st 30 min & then 600 mg/hr for the next 90 min.
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