Premarin Vaginal Cream Dosage & Drug Information

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Core Prescribing Info

Contents

Conjugated estrogens

Indications/Uses

Atrophic vaginitis, dyspareunia & kraurosis vulvae.

Dosage/Direction for Use

Usual dosage range: 0.5-2 g daily, intravaginally or topically, depending on severity of condition. Cyclic administration (3 wk on & 1 wk off) should be used. Severe cases of atrophic vaginitis Mucosa should 1st be conditioned w/ a short course of oral therapy (1.25 mg daily for approx 10 days). Institute vag treatment at lowest effective dosage & regularly reassess requirement for estrogen therapy.

Contraindications

Hypersensitivity. Undiagnosed abnormal uterine bleeding. Known, suspected or history of breast cancer. Known or suspected estrogen-dependent neoplasia (eg, endometrial cancer or hyperplasia). Active or history of arterial thromboembolic disease (eg, stroke, MI) or VTE (eg, DVT, pulmonary embolism). Known thrombophilic disorders (eg, protein C or S, or antithrombin deficiency). Active or chronic liver dysfunction or disease. Pregnancy.

MIMS Class

Preparations for Vaginal Conditions

ATC Classification

G03CA57 - conjugated estrogens ; Belongs to the class of natural and semisynthetic estrogens used in estrogenic hormone preparations.

Regulatory Classification

POM

Presentation/Packing

Form

Premarin Vaginal Cream 0.625 mg/g

Packing/Price

1's

Premarin Vaginal Cream

estrogens

Manufacturer:

PF Consumer Healthcare